Vivalyx is dedicated to saving lives of people suffering from organ failure by increasing the vitality and number of donor organs

Challenge

>1 Million

patients on waiting lists for organ transplantation

Not enough organs compared to need

>30%

complication rate for organ transplantations

Suboptimal quality of transplanted organs

>30%

complication rate for organ transplantations

Suboptimal quality of transplanted organs

Trend

Organ preservation is a key driver to increase the viability and number of organs for transplantation

SCS

Static Cold Storage

HOPE

Hypothermic Oxygenated Machine Perfusion

NMP

Normothermic Machine Perfusion

Status

NMP is optimal, but too complex and blood-based while blood is a limited resource

Several new preservation systems – the machines – are available, but what truly preserves the organ is the preservation solution – the liquid –

We are the first revolutionizing the preservation solution

Vivalyx Omnisol solution

Vivalyx Omnisol is a patented,
blood-free solution for all organs* and all preservation methods* with expected beneficial clinical outcomes for SCS, HMP, HOPE and NMP.

*Aspired intended uses after future step-wise registrations (Omnisol is not yet available)

Vivalyx Omnisol has preclinically been superior in many dimensions

Omnisol is the final optimized formulation of Ecosol, shown in the publications below

Static Cold Storage

Biliary complications rate of 0% compared to 57% using UW solution in rat SCS syngenic and allogenic liver transplantation models¹

Renal function of 45 min warm ischemia-damaged SCS preserved porcine kidneys comparable to non warm-ischemia damaged HTK controls²

Improved cold storage and oxygenated organ preservation compared to HTK in a clinically relevant porcine kidney transplantation model³

¹Tanaka H et al. Efficacy of the novel preservation solution Ecosol in a rat liver transplantation model. Transplant International Vol. 31 (Suppl.2), 5–15, 11

²Kalenski J et al. Improved preservation of warm ischemia-damaged porcine kidneys after cold storage in Ecosol, a novel preservation solution. Ann Transplant 2015 Apr 27;20:233-42

³Ernst LJ et al. A new organ preservation solution for cold storage and oxygenated organ preservation; First results from a clinically relevant porcine kidney transplantation model. IMIRT 2022, Poitiers, France

Hypothermic Oxygenated Machine Perfusion

Renal function of 45 min warm ischemia-damaged HOPE preserved kidneys comparable to non warm-ischemia damaged HTK controls¹

¹Kalenski J et al. Comparison of Aerobic Preservation by Venous Systemic Oxygen Persufflation or Oxygenated Machine Perfusion of Warm-Ischemia-Damaged Porcine Kidneys. Eur Surg Res. 2016;57(1-2):10-21

Normothermic Machine Perfusion

Improved antioxidant capacity, functional parameters and oxygenation compared to the current gold standard red blood cell containing perfusate during 6h NMP of warm-ischemia damaged porcine kidneys¹

Superior preservation of warm ischemia-damaged porcine kidneys after 6 hour normothermic machine perfusion using Omnisol solution compared to the gold standard red blood cell based perfusate²

¹Zarnitz L et al. Taurine as Antioxidant in a Novel Cell- and Oxygen Carrier-Free Perfusate for Normothermic Machine Perfusion of Porcine Kidneys. Antioxidants. 2023 Mar 21;12(3):768

²Zarnitz L et al. Improved preservation by Omnisol compared to red blood cell based perfusate for 6 hour normothermic machine perfusion of warm ischemia-damaged porcine kidneys. Transplantation 107(10S1):p 51-52, October 2023